MALDI MS-BASED HIGH-THROUGHPUT SCREENING METHOD FOR SUBSTANCES INHIBITING AGGREGATION OF ALZHEIMER'S AMYLOID BETA PEPTIDES

摘要

A MALDI MS based method for screening substances that inhibit aggregation of amyloid beta peptides. Such substances have a potential for treatment or prevention of Alzheimer's disease. An internal MALDI MS standard for quantification of content of amyloid beta peptide in the sample. Such a standard is based on using a spectrum of a known compound, such as human insulin (preferably B chain human insulin), as a reference.