BCL6-MEDIATED MODULATION OF CORTICAL DIFFERENTIATION OF NEURONAL PROGENITOR CELLS

摘要

The invention relates to methods, and corresponding uses, for modulating cortical differentiation of neuronal progenitor cells, in particular of cortical progenitors, encompassing methods for producing cortical neurons from neuronal progenitor cells, as well as methods for preventing cortical differentiation of the neuronal progenitor cells, through modulation of BCL6 activity in the neuronal progenitor cells. The invention further relates to the use of a non-human animal, which is BCL6 deficient or which comprises transgenic expression of BCL6, as a model for neural development, neural physiology or neurological diseases.