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GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS

机译：糖工程化毕赤酵母产生的粒细胞-结肠刺激因子

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摘要

Compositions comprising granulocyte-colony stimulating factor (GCSF) produced in a strain of Pichia pastoris glycoengineered to produce a GCSF wherein greater than 18% of the molecules comprise an 0-glycan with one mannose per (0-glycan is described. In particular aspects, the GCSF is PEGylated at the JV-terminus.

机译：在巴斯德毕赤酵母糖工程菌株中产生的包含粒细胞集落刺激因子（GCSF）的组合物经糖工程化以产生GCSF，其中大于18％的分子包含 0 -聚糖，其中每（描述了0 -聚糖，在特定方面，GCSF在JV末端被聚乙二醇化。 展开▼

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公开/公告号EP2494050A4

专利类型

公开/公告日2013-10-30

原文格式PDF

申请/专利权人 MERCK SHARP & DOHME CORP.;
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申请/专利号EP20100827363

发明设计人 LI HUIJUAN;MEEHL MICHAEL;BOBROWICZ PIOTR;GOMATHINAYAGAM SUJATHA;RIOS SANDRA;
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申请日2010-10-25

分类号C12N15/74;C12N1/00;

国家 EP

入库时间 2022-08-21 16:32:24

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1. 在糖工程化的酵母巴斯德毕赤酵母中对半乳糖同化途径的代谢工程化 [P] . 中国专利： CN102333872B . 2014.07.09

2. 在糖工程化的酵母巴斯德毕赤酵母中对半乳糖同化途径的代谢工程化 [P] . 中国专利： CN102333872A . 2012-01-25

3. GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS [P] . 欧洲知识产权局专利： EP2494050A1 . 2012-09-05

机译：糖工程化毕赤酵母产生的粒细胞-结肠刺激因子

4. GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS [P] . 美国专利： US2012213728A1 . 2012-08-23

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