TETRASUBSTITUTED BENZENES FOR TREATMENT OF EARLY ONSET ALZHEIMER'S DISEASE

摘要

Provided are compositions and methods for treating early onset familial Alzheimer's Disease. The compositions and methods can be used for improving one or more aspects of cognitive function in a patient suffering from early onset familial Alzheimer's Disease. In certain embodiments, the patient has autosomal dominant early-onset Alzheimer's Disease. In some embodiments, the patient has a mutation in at least one gene selected from the group consisting of PSEN 1, PSEN2 and APP. In some embodiments, the PSEN 1 mutation is a change or deletion in one or more amino acids. In some embodiments, the patient has a mutation in PSEN 1 (e.g., a missense mutation).