首页> 外国专利> MULTI-COMPONENT CHIMERA FOR USE AS A VACCINE AGAINST INFECTION BY LEISHMANIA SPP. IN MAMMALS

MULTI-COMPONENT CHIMERA FOR USE AS A VACCINE AGAINST INFECTION BY LEISHMANIA SPP. IN MAMMALS

机译：多组分化粪池，用于预防利什曼原虫 SPP感染的疫苗。在哺乳动物中

展开▼

页面导航

摘要

著录项

相似文献

摘要

The present invention relates to a multi-component chimera, HISA70, which comprises the H2A, H2B, H3, H4, A2 and HSP70 from Leishmania infantum. The invention further relates to an immunogenic composition that comprises said multi-component chimera and to the use of said composition in the preparation of a vaccine against Leishmania spp., with a view to conferring protection against leishmaniosis, including cutaneous leishmaniosis and visceral leishmaniosis, in mammals. 展开▼

机译：本发明涉及一种多组分嵌合体，HISA70，其包含来自婴儿利什曼原虫的I2H，H2B，H3，H4，A2和HSP70。本发明进一步涉及一种包含所述多组分嵌合体的免疫原性组合物，并且涉及所述组合物在制备抗利什曼原虫的疫苗中的用途，以赋予针对利什曼病的保护，包括哺乳动物的皮肤利什曼病和内脏利什曼病。展开▼

著录项

公开/公告号WO2013110824A1

专利类型

公开/公告日2013-08-01

原文格式PDF

申请/专利权人 UNIVERSIDAD COMPLUTENSE DE MADRID;
展开▼

申请/专利号WO2012ES00321

发明设计人 CARRION HERRERO FCO. JAVIER;DOMINGUEZ BERNAL GUSTAVO;ORDEN GUTIERREZ JOSE ANTONIO;DE LA FUENTES LOPEZ RICARDO;
展开▼

申请日2012-12-21

分类号C07K19;C12N15/30;A61K39/008;

国家 WO

入库时间 2022-08-21 16:31:43

相似文献

专利

外文文献

中文文献

1. 用于在哺乳动物中预防和治疗金迪普拉病毒感染的疫苗制剂 [P] . 中国专利： CN103228293A . 2013-07-31

2. 用于预防哺乳动物粘膜炎莫拉氏(布拉汉氏)菌感染的脂寡糖疫苗 [P] . 中国专利： CN1288384A . 2001-03-21

3. CHEMERA MULTICOMPONENT FOR USE AS A VACCINE AGAINST INFECTION BY LEISHMANIA SPP. IN MAMMALS. [P] . ES2415516R2 . 2013-08-19

机译：用作针对利什曼原虫SPP感染的疫苗的化学成分多组分。在哺乳动物中。

4. Chimera multicomponent for use as against infection by Leishmania spp vaccine. in mammals. [P] . ES2415516B2 . 2014-01-28

机译：用于抵抗利什曼原虫属spp疫苗感染的嵌合体多组分。在哺乳动物中。

5. Chimera multicomponent for use as against infection by Leishmania spp vaccine. in mammals. [P] . ES2415516A2 . 2013-07-25

机译：用于抵抗利什曼原虫属spp疫苗感染的嵌合体多组分。在哺乳动物中。

1. Two Cases of Multi-antibiotic Resistant Cronobacter spp. Infections of Infants in China [J] . CUI Jing Hua, YU Bo, XIANG Yun, 生物医学与环境科学（英文版） . 2017,第008期

2. Evaluation of in vitro and in vivo immunostimulatory activities of poly (lactic-co-glycolic acid) nanoparticles loaded with soluble and autoclaved Leishmania infantum antigens: A novel vaccine candidate against visceral leishmaniasi [J] . Emrah Sefik Abamor, Adil Allahverdiyev, Ozlem Ayse Tosyali, 亚太热带医药杂志（英文版） . 2019,第008期

3. Development of Leishmania vaccines: predicting the future from past and present experience [J] . Joshua Muli Mutiso, John Chege Macharia, Maria Ndunge Kiio, 生物医学研究杂志（英文版） . 2013,第002期

4. Molecular characterization of Trypanosoma cruzi and Leishmania spp. coinfection in mammals of Venezuelan coendemic areas [J] . M Viettri, L Herrera, CM Aguilar, Journal of vector borne diseases. . 2019,第3期

5. Proteinases as virulence factors in Leishmania spp. infection in mammals [J] . Mariana Silva-Almeida, Bernardo Acácio Santini Pereira, Michelle Lopes Ribeiro-Guimar?es, Parasites Vectors . 2012,第S1期

6. Serological Evidence of Infection by Leishmania (Leishmania) infantum (Synonym: Leishmania (Leishmania) chagasi) in Free-Ranging Wild Mammals in a Nonendemic Region of the State of Sao Paulo, Brazil [J] . Paiz Lais Moraes, Fornazari Felipe, Menozzi Benedito Donizete, Vector borne and zoonotic diseases . 2015,第11期

7. Automatic Annotation of Leishmania Infections in Fluorescence Microscopy Images [C] . Joao C. Neves, Helena Castro, Hugo Proenca, International conference on image analysis and recognition . 2013

8. Differential regulation of dendritic cell migration after Leishmania major and Leishmania amazonensis infection [D] . Soto Ruiz, Victor Raul 2007

9. Proteinases as virulence factors in Leishmania spp. infection in mammals [O] . Mariana Silva-Almeida, Bernardo Acácio Santini Pereira, Michelle Lopes Ribeiro-Guimarães, 2012

10. Proteinases as virulence factors in Leishmania spp. infection in mammals [O] . Mariana Silva-Almeida, Bernardo Acácio Pereira, Michelle Ribeiro-Guimarães, 2012

11. Attenuated Vaccine Useful for Immunizations Against Coccidioides Spp. Infections [R] . Cole, G. T., Okeke, C. N., Hung, C. Y. 2005

1. Immunization status and hospitalization for vaccine-preventable and non-vaccine-preventable infections in liver-transplanted children [J] . Palittiya Sintusek ,Yong Poovorawan . 世界肝病学杂志：英文版（电子版） . 2021,第1期

2. HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt [J] . Eman AE Abushady ,Magda MA Gameel ,John D Klena . 世界肝病学杂志：英文版（电子版） . 2011,第6期

3. PCV2疫苗用于预防临床猪圆环病毒相关疾病,减少感染PCV2b和猪支原体肺炎的公猪中PCV2病毒血症和精液排毒 [C] . Tanja Opriessnig ,徐亮 . 第21届国际猪兽医协会大会IPVS2010 . 2010

4. 睾酮在巨噬细胞及其杜氏利什曼原虫感染中的作用机制 [A] . 刘立民 . 2006