COLLAGEN-LIKE PEPTIDE HAVING STEALTH PROPERTY AND HIGH URINARY EXCRETION PROPERTY

摘要

The purpose of the present invention is to develop a drug carrier having a stealth property and a high urinary excretion property.The present invention provides: a collagen-like peptide which is a drug carrier having a stealth property and a high urinary excretion property; and a pharmaceutical composition containing the collagen-like peptide. In the pharmaceutical composition, a drug or a biologically active group is bound to the collagen-like peptide. Therefore, the pharmaceutical composition can be used for the detection, diagnosis or the like of a biological function or a biological condition. When a drug or a biologically active group which is responsive to oxidative stress in a living body is bound to the collagen-like peptide of the present invention, the collagen-like peptide may be used for the detection or diagnosis of oxidative stress occurring in radiation damages, fulminant hepatitis, anaphylactic shock, atherosclerosis, angina pectoris, cardiac infarction, Alzheimer's disease or Parkinson's disease. The pharmaceutical composition of the present invention may be a magnetic resonance imaging agent.