The present invention relates to an inhibitor of interferon regulatory factor 5 (IRF5) activity or expression for use in a method for reducing adipose tissue inflammation in a subject. The present invention also relates to a method for screening a plurality of candidate compounds useful for reducing adipose tissue inflammation comprising the steps consisting of (a) testing each of the candidate compounds for its ability to inhibit interferon regulatory factor 5 activity or expression and (b) and positively selecting the candidate compounds capable of inhibiting said interferon regulatory factor 5 activity or expression.
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