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SCAFFOLD-BASED ORGANOTYPIC CULTURE FORT THE LONG-TERM CULTIVATION OF HUMAN EPIDERMAL STEM-CELLS
SCAFFOLD-BASED ORGANOTYPIC CULTURE FORT THE LONG-TERM CULTIVATION OF HUMAN EPIDERMAL STEM-CELLS
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机译:基于支架的有机文化培养人类表皮干细胞的长期培养
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摘要
The present invention relates to organotypic cultures of epidermal cells and their uses for the screening of pharmaceutical and cosmetic agents. Specifically, means for the improvement of the long-term stability of said cultures are disclosed. Thus, the present invention contemplates a skin equivalent comprising (a) a dermal equivalent comprising a matrix comprising (i) nonwoven viscose fabric and (ii) fibroblasts and (b) keratinocytes. Moreover, the present invention contemplates a method for manufacturing said skin equivalent and a method for screening of agents capable of influencing skin, such as a therapeutic or cosmetic agent.
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