Total synthesis of the core tetrasaccharide of the lipopolysaccharide from Neisseria meningitidis

摘要

The present invention relates to the total synthesis of the α-GlcNAc-(1→2)-α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo core tetrasaccharide of the lipopolysaccharide from Neisseria meningitidis, the resulting product obtained by the total synthesis and α-GlcNAc-(1→2)-α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo for use as a vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.