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PREDICTING PLAQUE COMPOSITION AND PHENOTYPE IN CORONARY ARTERIES VIA HDL-SUBCLASS ANALYSIS, AND METHODS RELATED THERETO
PREDICTING PLAQUE COMPOSITION AND PHENOTYPE IN CORONARY ARTERIES VIA HDL-SUBCLASS ANALYSIS, AND METHODS RELATED THERETO
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机译:通过HDL-亚类分析预测冠状动脉斑块组成和表型及其相关方法
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摘要
The invention provides a method of identifying a subject at increased risk of cardiovascular disease (CVD) and/or soft plaque that provides an HDL subpopulation by separating the ApoA-I-containing HDL particles from a plasma sample from the subject, where the HDL particles include an alpha 1-4 (a1-4) subpopulation, a pre-alpha 1-4 (pre-a1-4) subpopulation, and a pre-beta 1-2 (?re-ß1-2) subpopulation, creating an HDL subpopulation profile by quantitating the HDL subpopulations, correlating the HDL subpopulation profile with reference HDL subpopulation profile values; and determining whether the subject has an increased risk, a borderline risk, or a low risk for CVD.
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