METHODS AND COMPOSITIONS TO ELIMINATE CHRONIC LYMPHOCYTIC LEUKEMIA AND OTHER HEMATOLOGIC MALIGNANT CELLS IN STROMAL MICROENVIRONMENT FOR CANCER THERAPY

摘要

The present invention regards compositions and methods for treating chronic lymphocytic leukemia in the in vivo tissue environment using selenium-containing compositions. In particular aspects, a selenium-comprising compound is administered to an individual wherein the CLL cells are in a stromal cell environment, wherein stromal factors modulate the selenium comprising compound to enhance its activity.