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METHOD TO GENERATE DOPAMINERGIC NEURONS FROM MOUSE AND HUMAN CELLS

机译：从小鼠和人类细胞产生多巴胺能神经元的方法

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摘要

The present invention relates to a method for reprogramming a differentiated non neuronal cell into a dopaminergic neuron comprising the step of inducing the expression in the differentiated non neuronal cell of at least the protein encoded by the Mash1 human gene or orthologues thereof and the protein encoded by the Nurr1 human gene or orthologues thereof, expression vectors, reprogrammed dopaminergic neuron and uses thereof.

机译：本发明涉及一种用于将分化的非神经元细胞重编程为多巴胺能神经元的方法，该方法包括以下步骤：诱导分化的非神经元细胞中至少由 Mash1 人基因或直向同源物及其由 Nurr1 人基因编码的蛋白质或直向同源物，表达载体，重编程的多巴胺能神经元及其用途。 展开▼

著录项

公开/公告号EP2652128A1

专利类型

公开/公告日2013-10-23

原文格式PDF

申请/专利权人 OSPEDALE SAN RAFFAELE S.R.L.;
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申请/专利号EP20110802339

发明设计人 BROCCOLI VANIA;CAIAZZO MASSIMILIANO;
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申请日2011-12-13

分类号C12N5/0793;

国家 EP

入库时间 2022-08-21 16:28:33

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