TNF-ALPHA SPECIFIC ANTIBODY AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING TNF-ALPHA-MEDIATED DISEASES

摘要

PURPOSE: A human TNF-alpha specific antibody containing a heavy chain constant region derived from human IgG2 and IgG4 is provided to minimize ADCC(Antibody-Dependent Cell-mediated Cytotoxicity) and CDC(Complement-Dependent Cytotoxicity).;CONSTITUTION: A human TNF-alpha specific antibody contains: a light chain containing a light chain constant region and a light chain variable region with light chain CDR1 of sequence number 1, light chain CDR2 of sequence number 2, and light chain CDR3 of sequence number 3; and a heavy chain containing a heavy chain constant region and a heavy chain variable region. A method for preparing the human TNF-alpha specific antibody comprises: a step of culturing a transformant; and a step of purifying the human TNF-alpha specific antibody from a culture medium. A pharmaceutical composition for preventing or treating TNF-alpha-mediated diseases contains the human TNF-alpha specific antibody.;COPYRIGHT KIPO 2013