SOLID PREPARATION OF ENTERIC SOLID DISPERSION AND METHOD FOR PRODUCING THE SAME

摘要

The present invention without impairing the dissolution of the solid dispersion, quickly to release the drug in the formulation can provide a solid preparation and a production method of the enteric solid dispersion. ; The present invention is a solid dosage form I of solid dispersion comprising the poorly soluble drug, an enteric polymer and collapse, the collapse I , while the average particle diameter is 10 to 100 also a specific surface area measured by the BET method of 1.0 m ² / g or more provides a low-substituted hydroxypropyl cellulose of the solid preparation of the enteric solid dispersion. In addition, while the average particle diameter as disintegrants 10 to 100 also a specific surface area measured by the BET method of 1.0 m ² / g or more by mixing a powder of low-substituted hydroxypropyl cellulose, poorly water-soluble spraying the enteric polymer dispersion or solution of the drug dissolved therein, and the assembly, provides a method for producing a solid dosage form comprising the enteric solid dispersion that is dried.