Generation composition for induced pluripotent stem cells with Bmi1 and histone deacetylase inhibitor treatment and method of manufacturing induced pluripotent stem cells using the same

摘要

the present invention is a) Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or Bmi1 a nucleic acid molecule encoding the protein; And b) relates to inhibitors of histone diacetyl la (histone deacetylase inhibitor) composition for inducing de-differentiation of a stem cell-like cells from somatic cells, and comprises a method for producing the stem cell-like cells using the same. 4 gene in conventional de-differentiation inducing factor according to the present invention the main (Oct4, Sox2, Klf4, and C-Myc / Oct4, Sox2, Nanog, Lin28) introducing a Bmi1 gene is only one factor, and the new addition of a low molecular weight chemical castle The advantage of being able to provide embryonic stem cell-like cells having the former are multipotent and relatively simple way to minimize the number of de-differentiation inducing factor by processing the histone diacetyl la inhibitors (histone deacetylase inhibitor). ;