1-(5-BROMO-2-HYDROXY-4-METHOXYPHENYL)ETHANONE HAVING ANTI-INFLAMMATORY EFFECTS AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: A 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone compound with anti-inflammatory effect and a pharmaceutical composition containing the same are provided to prevent or treat inflammation-mediated neurodegenerative diseases. CONSTITUTION: A 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone compound has inflammatory effect and is denoted by chemical formula 1. The compound blocks NF-kappaB and MAPK signaling pathway. The compound prevents or treats Alzheimer's disease, Parkinson's disease, myasthenia gravis, multiple sclerosis, Huntington's chorea, or progressive muscle dystrophy. The compound is derived from Paeonia suffruticosa ANER or hippocampus. A pharmaceutical composition for anti-inflammation contains the compound.