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TRANSGENIC ANIMAL WHICH EXPRESSES HUMAN GATA3 GENE UNDER THE REGULATION OF A CYTOMEGALOVIRUS PROMOTER, AND A METHOD FOR PRODUCING THE SAME
TRANSGENIC ANIMAL WHICH EXPRESSES HUMAN GATA3 GENE UNDER THE REGULATION OF A CYTOMEGALOVIRUS PROMOTER, AND A METHOD FOR PRODUCING THE SAME
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机译:在人巨细胞病毒启动子调控下表达人Gata3基因的转基因动物及其生产方法
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摘要
PURPOSE: A transgenic animal which expresses human GATA3 gene under the regulation of a cytomegalovirus promoter is provided to study the function of GATA3 protein in vivo and correlation between GATA3 protein and allergic disease.;CONSTITUTION: A transgenic fertilized egg(deposit number KCTC 12001BP) is prepared by transforming human GATA3 gene of sequence number 1. A transgenic mouse is produced by the fertilized egg. An expression cassette has human GATA3 gene which is linked with a cytomegalovirus promoter. A method for preparing a pCMV/hGATA3 expression cassette comprises: a step of amplifying a human GATA3 base sequence by PCR; and a step of cloning to pcDNA3.1 V5-His-TOPO vector.;COPYRIGHT KIPO 2013
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