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PHARMACEUTICAL COMPOSITE FORMULATION COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUG AND PROTON PUMP INHIBITOR, AND METHOD FOR PREPARING THE SAME
PHARMACEUTICAL COMPOSITE FORMULATION COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUG AND PROTON PUMP INHIBITOR, AND METHOD FOR PREPARING THE SAME
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机译:包含非甾体类抗炎药和质子泵抑制剂的药物复合制剂及其制备方法
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PURPOSE: A pharmaceutical composite with a double-layer tablet containing basic additives is provided to suppress generation of related compounds, to improve stability, and to enhance bioavailability, thereby being used as a therapeutic agent for treating hypertension and hypercholesterolemia. CONSTITUTION: A pharmaceutical composite comprises: a first layer containing non-steroidal anti-inflammatory drug (NSAID) or a pharmaceutically acceptable salt thereof; and a second agent containing proton pump inhibitors (PPIs) or a pharmaceutically acceptable salt thereof and a basic additive. The NSAID is naproxen. A method for manufacturing the pharmaceutical composite comprises the steps of: preparing granules for the first layer, containing naproxen or a pharmaceutically acceptable salt thereof; preparing granules for the second layer, containing PPIs and the basic additives; and tableting the granules. [Reference numerals] (AA) Double layer composite; (BB) Second layer: proton pump inhibitor + alkaline addictive; (CC) First layer: NSAID
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