PHARMACEUTICAL COMPOSITE FORMULATION COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUG AND PROTON PUMP INHIBITOR AND METHOD FOR PREPARING THE SAME

摘要

The present invention provides a pharmaceutical composition comprising a first layer comprising a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof; And a second layer containing a proton pump inhibitor or a pharmaceutically acceptable salt thereof and a basic additive, wherein the combined preparation of the present invention is in the form of a two-layered formulation comprising a basic additive , It can be used as a therapeutic agent for hypertension and hypercholesterolemia because it can improve the stability and increase the bioavailability by inhibiting the production of the flexible substance.