首页> 外国专利> Human Laminin 2 Chain LG3 Domain and Active Peptides Promoting Cell Adhesion, Spreading, Migration,and Neurite Outgrowth

Human Laminin 2 Chain LG3 Domain and Active Peptides Promoting Cell Adhesion, Spreading, Migration,and Neurite Outgrowth

机译:人层粘连蛋白2链LG3结构域和活性肽促进细胞粘附,扩散,迁移和神经突生长

摘要

The present invention relates to human laminin ± 2 chain LG3 domain and active peptides promoting cell adhesion, spreading, migration, and neurite outgrowth. More particularly, it was found that when nerve cells are incubated using human laminin ± 2 chain LG3 domain and active peptides in the LG3 domain, cell adhesion, spreading, migration, and neurite outgrowth of nerve cells promote and the promotion of cell adhesion, spreading, migration, and neurite outgrowth of nerve cells are integrin-mediated and achieved by the activation of PKC ´ and FAK phosphorylation. Thus, the present invention can be very useful for researches on cell adhesion, spreading, migration, and neurite outgrowth activities of cells which are focused on nerve cells and mediated by various extracellular matrix proteins including laminin, manufacture of artificial nerve conduits, burns treatment, wounds treatment, and tissue regeneration.
机译:本发明涉及人层粘连蛋白±2链LG3结构域和促进细胞粘附,扩散,迁移和神经突增生的活性肽。更具体地,发现当使用人层粘连蛋白±2链LG3结构域和LG3结构域中的活性肽温育神经细胞时,神经细胞的细胞粘附,扩散,迁移和神经突向外生长促进并且促进细胞粘附,扩散。神经细胞的迁移,迁移和神经突生长是整合素介导的,并通过激活PKC´和FAK磷酸化来实现。因此,本发明对于研究集中于神经细胞并由包括层粘连蛋白的各种细胞外基质蛋白介导的细胞的细胞粘附,扩散,迁移和神经突向外生长活性的研究,制造人造神经导管,烧伤治疗,伤口治疗和组织再生。

著录项

  • 公开/公告号KR101219512B1

    专利类型

  • 公开/公告日2013-01-11

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20110022946

  • 发明设计人 민병무;

    申请日2011-03-15

  • 分类号A61K38/16;A61K38/08;A61K38/10;A61P17/02;

  • 国家 KR

  • 入库时间 2022-08-21 16:25:57

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