PHARMACEUTICAL COMPOSITION COMPRISING (E)-N-(2-OXO-1-(4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)-2-(2-((4-OXO-4H-CHROMEN-3-YL)METHYLENE)HYDRAZINYL)ETHYL)BENZAMIDE FOR PREVENTING AND TREATING OF NEURODEGENERATIVE DISEASE

摘要

PURPOSE: A pharmaceutical composition containing (E)-N-(2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-2-(2-((4-oxo-4H-chromen-3-yl)methylene)hydrazinyl)ethyl)benzamide for preventing and treating neurodegenerative diseases is provided to suppress A beta decomposition and to prevent and treat Alzheimer' disease. CONSTITUTION: A method for screening an agent for preventing and treating Alzheimer's disease, Parkinson's disease, amylotrophic lateral scelerosis(ALS), or dementia comprises: a step of simultaneously and sequentially treating a GCP II(Glutamate Carboxypeptidase II)-expressing cell line with a compound of chemical formula 1 and candidate materials in vitro; a step of measuring the activation level of a S1 or S1' pocket of GCP ii in the cell line; and a step of selecting a candidate material which increases or decreases the activation level compared with a control group.