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PREPARATION OF PROTECTIVE ANTIGEN FROM BACILLUS ANTHRACIS
PREPARATION OF PROTECTIVE ANTIGEN FROM BACILLUS ANTHRACIS
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机译:炭疽杆菌保护性抗原的制备
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摘要
A polynucleotide sequence is provided, comprising: a nucleic acid sequence having at least 75% identity to SEQ ID NO: 1, wherein said nucleic acid sequence encodes recombinant Bacillus anthracis Protective Antigen (rPA); or a fragment of said nucleic acid sequence wherein said fragment encodes a fragment of recombinant Bacillus anthracis Protective Antigen (rPA). Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing rPA or a fragment thereof. The invention further provides antigenic compositions and corresponding methods and uses for inducing an immune response.
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机译:提供了一种多核苷酸序列,其包含:与SEQ ID NO:1具有至少75%同一性的核酸序列,其中所述核酸序列编码重组炭疽芽孢杆菌保护性抗原(rPA);或所述核酸序列的片段,其中所述片段编码重组炭疽芽孢杆菌保护性抗原(rPA)的片段。还提供了包含本发明的多核苷酸序列的表达载体和宿主细胞,以及产生rPA或其片段的方法。本发明进一步提供了用于诱导免疫应答的抗原组合物以及相应的方法和用途。
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