Composition comprising local injection preparation for endoscopic mucosal resection

摘要

PURPOSE: A topical injection composition for endoscope demucosation is provided to extend uplift time of mucous lesion part and to enhance operationality. CONSTITUTION: A topical injection composition for endoscope demucosation comprises alginate and cation. Cation is cation or the salt of calcium, potassium, sodium, barium, magnesium, gadolinium, lithium, copper, iron, aluminum, strontium, tin, zinc, chrome or organic cation, calcium glutaminate, poly(amino acid), poly(ethylene imine), poly(vinylamine), poly(allyl amine) or polysaccharide. Cation is included in a form of calcium-gluconate, calcium chloride(CaCl2), barium chloride(BaCl2) or magnesium chloride(MgCl2). The hydrogel composition additionally includes nano-particles. The nano-particle is gadolinium nano-particle, iron oxide nano-particle, barium nano-particle, gold or nano-silver particle, gadolinium oxide, barium sulfate, and silica nano-particle or iodine nano-particle. The endoscope demucosation is operated on esophageal cancer, stomach cancer, mamillary region cancer or colon cancer.