A Composition for Overcoming Resistance to Anticancer Drugs comprising Methyl pheophorbide

摘要

PURPOSE: A pharmaceutical composition for overcoming resistance to an anticancer agent is provided to suppress the activity of hemo oxygenase (HO) increased in cancer cells using methyl pheophorbide (MPP), thereby remarkably increasing apoptotic sensitivity in cancer cells with anticancer agent resistance. CONSTITUTION: A pharmaceutical composition for overcoming resistance to an anticancer agent contains MPP as an active ingredient. The anticancer agent is cisplatin. The effective concentration of MPP is 10 uM. A composition for suppressing HO contains MPP as an active ingredient.