Preventing and treating composition for hyperlipidemia containing the Platycodon grandiflorum fraction from the Platycodon grandiflorum roots with high purity platycosides

摘要

PURPOSE: A composition for preventing and treating hyperlipidemia which contains platicodon grandiflorum A. DC fractions including high purity platicoside is provided to prevent accumulation of cholesterol in the hepatic tissue. CONSTITUTION: A composition for preventing and treating hyperlipidemia includes platicodon grandiflorum A. DC fraction as an active ingredident. The Platycodon grandiflorum A. DC fractions are obtained by the following steps: dissolving ethanol crude extract in ethanol and adding acetone; removing precipitates and concentrating filtrate in order to obtain Platycodon grandiflorum A. DC ethanol-acetone fraction; obtaining water fraction by dissolving the platicoside ethanol-acetone fraction and concentrating water layer by dividing ethylacetate; obtaining butanol fractions by concentrating the butanol layer after separting the water layer from the butanol layer; and isolation purifying the Platycodon grandiflorum A. DC fractions which contain high purity Platicodi Radix platicoside by using reverse phase cartridge chromatography. More than 1micro gram/mL of the Platycodon grandiflorum A. DC fractions is included.