D-Aptide Having Maintained Target Affinity and Enhanced Stability

摘要

The invention (a) between the strands (interstrand) non-covalent bond is formed parallel (parallel), anti-parallel (antiparallel) or parallel (parallel) and anti-parallel (antiparallel) structure stabilizing region comprising a D- amino acid strands (structure stabilizing region ); And (b) wherein the structure stabilizing region of both ends of the binding is may randomly selected each n and m D-amino acids including a target binding region I (target binding region I) and a target binding region Ⅱ (target binding region Ⅱ ) D- specific aptamer that binds to a target containing - D-Aptide like peptide (), the D-Aptide has affinity for the target compared to the L-protein Aptide degree of decomposition, while maintaining the stability of the enzyme sequence has the same or the opposite direction as the L-Aptide, it characterized in that the increase relates to the app D- lactide (D-Aptide). D-Aptide of the present invention is different from the conventional technical common sense, as compared to the L-Aptide target affinity is substantially the same as and stability is greatly improved. Not only has the D-Aptide the medicament as a purpose of the present invention, may be used for a target for in vivo substance detection, in vivo molecular imaging, in vitro cell imaging, and drug delivery, it can also be used to escort molecules have. ;