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COMPOSITIONS OF STILBENE POLYPHENOLS DERIVATIVES AND THEIR APPLICATION FOR THE FIGHT AGAINST PATHOLOGY AND AGING OF LIVING ORGANISMS

机译:苯乙烯多酚衍生物的组成及其在对抗生命有机体病理和衰老中的应用

摘要

1. Compositions of derivatives of polyphenols, characterized in that the derivatives of polyphenols contain monomers, oligomers or polymers consisting of units of formula (I): these units are characterized by the simultaneous presence of a resorcinol type ring (ring A) and a phenol type ring (ring B) connected to each other with another carbon fragment C, wherein said derivatives are superactivated with respect to nucleophilic activity by alkylation of at least one phenolic group of each unit and stabilized by esterification and a mixture of fatty acids, mainly unsaturated, (AGI) of all other phenolic functions. 2. Compositions according to claim 1, characterized in that the indicated units of ring A and B are fused and then fragment C is absent, as in phloroglucinol of formula (II): 3. Compositions according to claim 1, characterized in that the rings A and B in the indicated units differ from each other, and fragment C consists of 2 carbons, which are sp2-hybridized and form a vinyl bond, as in resveratrol of the formula (III): or fragment C consists of sp3-hybridized carbons and is a junction with monomers to form oligomers and polymers. 4. Compositions according to claim 1, characterized in that the number of α-alkyl groups per unit is not equal to the number of hydroxyl groups falling on average per structural unit The composition according to claim 4, characterized in that the number of hydroxyl groups per unit on average is 1 or 2.6. Compositions according to claim 1, characterized in that the alkyl or alkyl groups are methyl, isopropyl or tert-butyl groups. Compositions according to claim 1, characterized in that said ester groups are
机译:1.多酚衍生物的组合物,其特征在于多酚衍生物包含由式(I)单元组成的单体,低聚物或聚合物:这些单元的特征在于间苯二酚型环(环A)和苯酚同时存在型环(B环)与另一个碳片段C相互连接,其中所述衍生物通过每个单元的至少一个酚基团的烷基化而在亲核活性方面是超活化的,并通过酯化和脂肪酸混合物(主要是不饱和的)稳定化,(AGI)所有其他酚功能。 2.根据权利要求1的组合物,其特征在于环A和B的所示单元稠合,然后不存在片段C,如式(II)的间苯三酚:3.根据权利要求1的组合物,其特征在于,所述环所示单元中的A和B彼此不同,片段C由2个碳组成,它们被sp2-杂化并形成乙烯基键,如式(III)的白藜芦醇:或片段C由sp3-杂化碳组成并与单体连接形成低聚物和聚合物。 4.根据权利要求1所述的组合物,其特征在于,每单元的α-烷基的数目不等于平均每个结构单元上的羟基的数目。5.根据权利要求4所述的组合物,其特征在于,羟基的数目每单位平均为1或2.6。 2.根据权利要求1的组合物,其特征在于烷基或烷基是甲基,异丙基或叔丁基。 2.根据权利要求1的组合物,其特征在于所述酯基是

著录项

  • 公开/公告号RU2010123790A

    专利类型

  • 公开/公告日2013-01-20

    原文格式PDF

  • 申请/专利权人 КОДАЛИ (FR);

    申请/专利号RU20100123790

  • 发明设计人 ВЕРКОТЕРЕН ЖОЗЕФ (FR);

    申请日2008-11-17

  • 分类号A61K31/23;

  • 国家 RU

  • 入库时间 2022-08-21 16:23:54

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