ISOLATES AND COMPOSITIONS OF THE TORQUE TENO VIRUS (TENO)

摘要

1. The selected polynucleotide sequence containing a polynucleotide selected from the group consisting of: (a) DNA sequence of the TTV genotype 2 (Torque Teno virus) 13 (SEQ ID NO: 1); TTV10 genotype 2 DNA sequences (SEQ ID NO: 2); or a fragment thereof that encodes a TTV capsid protein or a fragment of said protein; (a) a DNA sequence of genotype 1 selected from the group consisting of ttvg1-7 (SEQ ID NO: 4), ttvGT1-17 (SEQ ID NO: 5), ttvGT1-21 (SEQ ID NO: 6), ttvgt1-27 (SEQ ID NO: 3) and ttvgt1-178 (SEQ ID NO: 7), or a fragment thereof that encodes a TTV capsid protein or a fragment of the specified protein; (b) a sequence complementary to any sequence from (a); (c) a polynucleotide that hybridizes to a sequence from (a) or (b) under stringent conditions defined as hybridization with filter-bound DNA in 0.5 M NaHPO, 7% SDS, 1 mM EDTA at 65 ° C and washing in 0.1 × SSC / 0.1% SDS at 68 ° C. (g) a polynucleotide that is at least 70% identical to the polynucleotide from (a) or (b); ( e) a polynucleotide that is at least 80% identical to the polynucleotide from (a) or (b); (e) a polynucleotide that is at least 90% identical to the polynucleotide from (a) or (b); and (g) a polynucleotide that is at least 95% identical to the polynucleotide from (a) or (b). 2. A RNA polynucleotide molecule complementary to any polynucleotide DNA sequence according to Claim 1.3. A vector or plasmid containing the polynucleotide according to claim 1 or 2.4. A host cell containing a vector or plasmid according to claim 3.5. A virus that can be expressed from the nucleotide sequence of claim 1, wherein said virus is live, either fully or partially attenuated. The vaccine containing the virus according to claim 5.7. A polypeptide encoded by any