ISOLATES AND COMPOSITIONS OF THE TORQUE TENO VIRUS (TTV)

摘要

1. The selected polynucleotide sequence containing a polynucleotide selected from the group consisting of: (a) DNA sequence of the TTV genotype 2 (Torque Teno virus) 13 (SEQ ID NO: 1); a TTV10 genotype 2 DNA sequence (SEQ ID NO: 2) or a fragment thereof that encodes a TTV capsid protein or a fragment of the protein; (a) a genotype 1 DNA sequence selected from the group consisting of ttvGT1-17 (SEQ ID NO: 5) , ttvGT1-21 (SEQ ID NO: 6), ttvgt-l-27 (SEQ ID NO: 3) and ttvgtl-178 (SEQ ID NO: 7) or a fragment thereof that encodes a TTV capsid protein or a fragment of the protein; ( b) a sequence complementary to any sequence from (a); (c) a polynucleotide that hybridizes to a sequence from (a) or (b) under stringent conditions defined as hybridization with DNA, knitted with a filter in 0.5 M NaHPO, 7% SDS, 1 mM EDTA at 65 ° C and washing in 0.1 × SSC / 0.1% SDS at 68 ° C. (g) polynucleotide, which is at least at least 70% identical to the polynucleotide from (a) or (b); (e) a polynucleotide that is at least 80% identical to the polynucleotide from (a) or (b); (e) a polynucleotide that is at least 90% identical to the polynucleotide of (a) or (b); and (g) a polynucleotide that is at least 95% identical to the polynucleotide from (a) or (b). 2. A RNA polynucleotide molecule complementary to any polynucleotide DNA sequence according to Claim 1.3. A vector or plasmid containing the polynucleotide according to claim 1 or 2.4. A host cell containing a vector or plasmid according to claim 3.5. A virus that can be expressed from the nucleotide sequence of claim 1, wherein said virus is live, either fully or partially attenuated. The vaccine containing the virus according to claim 5.7. Polynucleotide DNA Vaccine