SELECTIVE PROTIVOTUBERKULEZYNE agent are asymmetrically 3,6-disubstituted 1,2,4,5-tetrazine AND METHOD FOR THEIR PREPARATION

摘要

1. Selective antituberculosis agents, which are 3-substituted amino-6- (3,5-dimethylpyrazole-1-yl) -1,2,4,5-tetrazine of formula R = amino Agde, CC--alkyl, 3-hydroxy -5-hydroxypentyl, propyn-2-yl, ethylindole, adamantyl, aryl selected from optionally substituted phenyl, heteryl selected from quinolin-3-yl, pyridyl, phenyl substituted with a substituent selected from the group consisting of methyl, chloro , methoxy, and pyridyl is substituted with substituents selected from chloro, metil.2. Selective antituberculosis agents, which are 3-substituted hydrazino-6- (3,5-dimethylpyrazole-1-yl) -1,2,4,5-tetrazine of formula B or BR = a hydrogen atom or methyl; R = methyl, 1-phenylpropen-1-yl, aryl selected from optionally substituted phenyl, heteryl selected from furyl, pyridyl, wherein the phenyl is substituted with 1-3 substituents selected from the group consisting of bromo, chloro, methoxy, nitro, , a hydroxy group, n = 0, 1, 2.3. A method for producing 3-gidrazinozameschennyh 6- (3,5-dimethylpyrazole-1-yl) -1,2,4,5-tetrazine of formula B or C according to claim 2, which comprises reacting equimolar amounts of 3-hydrazino-6- (3 5-dimethylpyrazole-1-yl) -1,2,4,5-tetrazine and aryl, getarilaldegida, aromatic or aliphatic ketone under heating in an organic solvent, characterized in that the process is carried out under the effect of 200 watt microwave irradiation at a temperature of 55-60 ° C for 15-20 min, and in acetonitrile is used as the organic solvent.