RESISTANCE OF PLANTS TO OOMYCETES, INFLUENCED BY AN ANTIBODIES Fusion

摘要

1. A fusion protein containing at least one anti-oomycete protein or peptide (PHB) associated with an antibody or antibody fragment that specifically recognizes the Oomycota epitope. 2. The fusion protein according to claim 1, wherein the PHB is selected from the group consisting of Cec, D4E1, GR7, Mag, and Swordsman (MTK). The fusion protein according to claim 1 or 2, wherein the antibody or fragment thereof specifically recognizes the epitope of Phytophthora ssp., Pythium ssp., Peronospora ssp. And Pseudoperonospora ssp., Preferably Phytophthora infestans, Phytophthora capsici, Phytophthora cactorthnam phththumthophthnamthoma, Phytophthora cactorumthymthum. four. The fusion protein according to claim 1, wherein the antibody or fragment thereof is an F (ab ′) 2 fragment, a Fab fragment, scFv, a bispecific scFv, a trispecific scFv, a diatel, a single domain antibody (dAb), a mini-antibody, or a molecular recognition unit (EMP). 5. The fusion protein of claim 4, wherein the antibody fragment is scFv having a sequence selected from the group consisting of SEQ ID N0: 61 - SEQ ID NO: 69.6. The fusion protein of claim 1, further comprising at least one N-terminal and / or C-terminal tag, at least facilitating the detection and / or purification of the fusion protein. The fusion protein according to claim 6, wherein the label is selected from the group consisting of c-myc, his, his, tag54, FLAG, HA, HSV-, T7, S, streptococcal and E-labels. The fusion protein of claim 1, further comprising a cell targeting sequence. The fusion protein of claim 8, wherein the cell targeting sequence is a sequence for isolating or localizing the fusion protein in cell divisions or organelles, preferably in the apoplast, vacuole, internal and / or external membranes or lumen of the endoplasmic reticulum (ER). 10. The fusion protein of claim 1, wherein the PHB and the antibody or fragment thereof are linked by a peptide