Nucleic Acid and Amino Acid Sequences of Monkey Adenovirus, VECTors Containing Indicated Sequences, and Their Application

摘要

1. An isolated polynucleotide that encodes an adenoviral fibrillar protein or a functional derivative thereof and which is selected from the group consisting of: (a) a polynucleotide encoding a polypeptide that has an amino acid sequence according to any of SEQ ID NOs: 14-19, 50 and 53; (b) a polynucleotide encoding a functional derivative of a polypeptide according to any of SEQ ID NOs: 14-19, 50 and 53, wherein said functional derivative comprises a deletion, insertion and / or replacement of one or more amino acid residues, and (c) a polynucleotide, iruyuschego functional derivative thereof having an amino acid sequence that is at least 85% identical over its entire length amino acid sequence of any of SEQ ID NO: 14-19, 50 and 53.2. An isolated polynucleotide that encodes adenovirus hexon protein or a functional derivative thereof and which is selected from the group consisting of: (a) a polynucleotide encoding a polypeptide that has the amino acid sequence according to any of SEQ ID NOs: 20-25, 51 and 54; (b ) a polynucleotide encoding a functional derivative of a polypeptide according to any of SEQ ID NOs: 20-25, 51 and 54, wherein said functional derivative comprises a deletion, insertion and / or replacement of one or more amino acid residues, and (c) a polynucleotide encoding o a functional derivative having an amino acid sequence that is at least 95% identical along the entire length of any amino acid sequence of SEQ ID NOs: 20-25, 51 and 54.3. An isolated polynucleotide that encodes the adenoviral penton protein or its functional derivative and which is selected from the group