Imidazole-substituted pyrimidines useful in the treatment of diseases associated with kinase-3 glycogen synthase, such as Alzheimer's disease

摘要

1. The compound of General formula (I) where R is hydrogen or fluorine, R and R are selected from hydrogen or methyl; or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1, wherein R1 is fluoro; or a pharmaceutically acceptable salt thereof. 3. The compound according to any one of claims 1 or 2, wherein R and R are hydrogen; or a pharmaceutically acceptable salt thereof. 4. A compound according to any one of claims 1 or 2, wherein R 1 is methyl; or a pharmaceutically acceptable salt thereof. 5. The compound according to claim 4, where R is (R) methyl; or a pharmaceutically acceptable salt thereof. 6. A compound according to any one of claims 1 or 2, wherein R and R are methyl; or a pharmaceutically acceptable salt thereof. 7. A compound according to claim 1, wherein R 1 is fluoro, R 1 and R 1 are hydrogen; or a pharmaceutically acceptable salt thereof. 8. The compound, which is N- (2,5-difluoro-4- (morpholinomethyl) phenyl) -5-fluoro-4- (2-methyl-1- (tetrahydro-2H-pyran-4-yl) -1H-imidazole -5-yl) pyrimidin-2-amine; or a pharmaceutically acceptable salt thereof. 9. The compound, which is N- (2,5-difluoro-4- (morpholinomethyl) phenyl) -5-fluoro-4- (2-methyl-1- (tetrahydro-2H-pyran-4-yl) -1H-imidazole -5-yl) pyrimidin-2-amine disuccinate. 10. The compound, which is N- (2,5-difluoro-4- (morpholinomethyl) phenyl) -5-fluoro-4- (2-methyl-1- (tetrahydro-2H-pyran-4-yl) -1H-imidazole -5-yl) pyrimidin-2-amine hemisuccinate. 11. The compound, which is: 5-fluoro-N- (2-fluoro-4- (morpholinomethyl) phenyl) -4- (2-methyl-1- (tetrahydro-2H-pyran-4-yl) -1H-imidazole- 5-yl) pyrimidin-2-amine; N- (4 - (((3S, 5S) -3,5-dimethylmorpholino) methyl) -2,5-difluorophenyl) -5-fluoro-4- (2-methyl- 1- (tetrahydro-2H-pyran-4-yl) -1H-imidazol-5-yl) pyrimidin-2-amine; N- (2,5-difluoro-4 - (((S) -3-methylmorpholino) methyl ) phenyl) -5-fluoro-4- (2-methyl-1- (tetrahydro-2H-pyran-