ALGINATE OLIGOMERS FOR APPLICATION IN OVERCOMING MULTIPLE DRUG STABILITY IN BACTERIA

摘要

1. A method of overcoming resistance to at least one antibiotic in an MDR bacterium (a bacterium having multidrug resistance), comprising bringing said bacterium into contact with an alginate oligomer together with an antibiotic. The use of an alginate oligomer for the manufacture of a medicament for use with at least one antibiotic in the treatment of a subject infected, presumably infected, or at risk of infection with an MDR bacterium, to overcome antibiotic resistance in said bacterium. 3. A product containing an alginate oligomer and an antibiotic in the form of a combined preparation for the separate, simultaneous or sequential use in the treatment of a subject infected, presumably infected or at risk of infection with an MDR bacterium, to overcome antibiotic resistance in said bacterium. 4. An in vitro method of controlling the contamination of an area with an MDR bacterium, comprising contacting said area and / or said bacterium with an alginate oligomer together with an antibiotic to which said bacteria are resistant. The method of claim 1, wherein the bacterium is resistant to three or more classes of antibiotics selected from macrolides, β-lactams, tetracyclines, polypeptide antibiotics and quinolones. The method of claim 5, wherein the bacterium is resistant to three or more antibiotics selected from azithromycin, clarithromycin, dirithromycin, erythromycin, troleandomycin, roxithromycin, spiramycin, aztreonam, imipenem, meropenem, erytapenem, dorupenem, bipenem, bipenem, bipenem , cefixime, cefdinir, cefditorin�