SYNTHETIC PEPTIDES WITH A NON-DRUG TYPE OF ANALGETIC ACTION

摘要

Synthetic peptides of the general formula 1 [SEQ ID NO: 1] XDL - XDL1 - XDL2 - L-Lys - L-Leu - XDL3 - L-Thr - R2 (I), where XDL is the absence of an amino acid or L-Tyr, XDL1 is one from amino acids: L-Leu, L-Ala or D-Ala, XDL2 - one of the amino acids: L-His, D-His, L-Ala or D-Ala, XDL3 - one of the amino acids: L-Gln, L-Ala or D-Ala; R2 — OMe or NH, or peptides — retro-inversions of formula (I) having the reverse amino acid sequence, replacing the L-form of amino acids with the D-form and the D-form of amino acids with the L-form, general formula 2 [SEQ ID NO: 2] D-Thr - XDL4 - D-Leu - D-Lys - XDL5 - XDL6 - XDL7 - R2 (II), where XDL4 is one of the amino acids: D-Gln, D-Ala or L-Ala; XDL5 - one of the amino acids: D-His, L-His, D-Ala or L- Ala, XDL6 - one of the amino acids: D-Leu, D-Ala or L-Ala, XDL7 - the absence of an amino acid or D-Tyr, R2 - OMe or NH, as painkillers with a non-narcotic type of analgesic effect.