METHOD FOR SYNTHESIS OF (Z)-3-(2-BUTOXY-3'-(3-HEPTYL-1-METHYLUREIDO) BIPHENYL-4-YL)-2-METHOXYACRYLIC ACID

摘要

FIELD: chemistry.;SUBSTANCE: present invention relates to a novel method for synthesis of (Z)-3-[2-butoxy-3'-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I) and intermediate compounds (XII), (XIII) and (XIV). The disclosed method involves reaction of a sulphonate of formula (XII), where R₂ denotes methyl, trifluoromethyl, phenyl or tolyl, with 3-heptyl-1-methyl-1-[3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]urea of formula (IIIb) or with a corresponding boronic acid of formula (IIIa).;EFFECT: easier synthesis owing to fewer steps.;8 cl, 1 ex, 2 dwg