METHOD FOR PREVENTION OF SKELETAL MUSCLE ATROPHY AFTER FUNCTIONAL UNLOADING

摘要

FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to physiology and space medicine. The method for prevention of skeletal muscle atrophy after functional unloading involves administering 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) which increases an amount of muscle heat shock proteins and further reduces a level µ-calpain.EFFECT: invention enabling managing the negative effects of hypokinesia or gravity unloading through the enhanced inhibition key signalling pathways initiating atrophy.9 dwg