MICROEMULSIVE COMPOSITIONS FOR CREATION OF TRANSDERMAL AND TRANSMUCOSAL FORMS OF PHARMACEUTICAL MEDICATIONS AND COSMETIC PREPARATIONS, AND METHOD OF THEIR APPLICATION

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention is intended for application in pharmacy and cosmetology. Microemulsive composition has water and oil phases for transdermal and/or transmucosal introduction, contains, at least, one water- or fat-soluble active substance, activator of transdermal or transmucosal transfer, and main and additional emulsifiers. As main emulsifier used is synthetic emulsifier, and as additional emulsifier non-polar emulsifiers and/or polar emulsifiers are used. Microemulsive composition can be applied for preparing transdermal cosmetic preparations, for preparing transdermal and/or transmucosal medications.;EFFECT: ensuring high bioavailability of transdermal and transmucosal forms of medications and cosmetic substances through intact skin and mucous membranes due to creation of stable and biocompatible microemulsive compositions, capable of transferring water- and fat-soluble medications and cosmetic substances with molecular weight to ~6000 Da through intact skin.;10 cl, 8 dwg, 3 tbl, 8 ex