T CELL SPECTRUM BROADENING FOR SUB-DOMINANT EPITOPE INCLUSION BY VACCINATION WITH ANTIGENS DELIVERED AS PROTEIN FRAGMENTS OR PEPTIDE COCKTAILS

摘要

FIELD: medicine.;SUBSTANCE: group of inventions is based on the induction of recognising dominant and sub-dominant responses to epitopes of any antigen important for preventing or treating a chronic diseases by immunisation with pools of overlapping fragments of a desired antigen. A T cell spectrum is primed to be included both for a principal epitope recognised when using an intact molecule for immunisation and induced by a chronic infection, and for inducing a much wider and more balanced response to the number of the sub-dominant epitopes. An elicited T cell response to the sub-dominant epitopes is important to protect against the chronic disease which itself induces the response focused on the principal epitopes only.;EFFECT: group of inventions requires no advance information on the exact localisation and identity of the sub-dominant epitopes, as well as recognition thereof in the human population, and extends the range of T-cells and thereby total number of epitopes recognised by the specific T cells primed by vaccination against several principal epitopes to the variety of the epitopes of the vaccine importance.;12 cl, 13 dwg, 5 ex