THREE-DIMENSIONAL MATRIXES FROM STRUCTURED POROUS MONETITE FOR TISSUE ENGINEERING AND BONE REGENERATION AND METHOD OF THEIR OBTAINING

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to three-dimensional matrix from monetite with structured porosity, method of claimed matrix synthesis and mould for its obtaining and application of monetite matrix for regeneration of bone structure. In its structure claimed monetite matrix has vertical cylindrical macropores with diameter from 350 to 650 mcm, which cross matrix in longitudinal direction from one end to another, and are located at from 0.4 mm to 0.6 mm distance from each other. Mould for obtaining claimed matrix is provided with uniformly allocated cogs with diameter 350-650 mcm, which are uniformly located at 0.4 - 0.6 mm distance from each other. Method of synthesis of monetite matrix includes stages of mixing basic calcium phosphates, acid calcium phosphates, pore-forming agent and setting retardant, and solidification by adding distillated water with formation of liquid phase, filling mould with said liquid phase, sterilisation of formed precursor material and its thermal transformation in monetite.;EFFECT: inventions are directed at obtaining matrix from bio-material monetite with predetermined porosity, which ensures possibility of neo-vascularisation and inoculation with cells and is bioactive, non-cytotoxic, non-mutagenic and hemo-compatible.;44 cl, 38 dwg, 11 ex