METHOD OF DETECTING PRESENCE OF SYSTEMIC REACTION OF CONNECTIVE TISSUE, CONDITIONED BY DEVELOPMENT OF SYNDROME OF COMBINED DYSTROPHIC-DEGENERATIVE CHANGES OF MESENCHYMAL DERIVATIVES IN CASE OF LOCAL CHRONIC INFLAMMATORY PROCESS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to field of medicine, namely to pathological anatomy, and can be used for specifying pathogenesis of manifestations of connective tissue pathology. For this purpose non-specific signs of chronic inflammation are identified in blood. Biopsy of skin is carried out. Sections of connective tissue sample are made. Sulfated glycosaminoglycans (SGAG), immunohistochemical markers of apoptosis induction, mast cells are identified in obtained sections. Presence of non-specific signs of chronic inflammation in blood, as well as sharp reduction of SGAG content in reticular dermis, proapoptotic changes of cell elements of reticular dermis, appearance of mast cells in external layers of reticular dermis are used to make conclusion about presence of systemic reaction of connective tissue, conditioned by development of syndrome of combined dystrophic-degenerative changes of mesenchymal derivatives in case of local chronic inflammatory process (SCDDCMD IN CASE OF LCIP), is made.;EFFECT: method makes it possible to carry out differential diagnostics between diseases of connective tissue of hereditary or involutional etiology, and states, conditioned by systemic reaction of connective tissue at the background of SCDDCMD IN CASE OF LCIP development, as well as to diagnose prenosological pathologic changes of connective tissue to presence of chronic inflammation focus.;3 cl, 1 tbl