首页> 外国专利> 5-(2-{6-(2,2-DIFLURO-2-PHENYLETHOXY)HEXYLAMINO}-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE HEMINAPADISYLATE AS β2 ADRENERGIC RECEPTOR AGONIST

5-(2-{6-(2,2-DIFLURO-2-PHENYLETHOXY)HEXYLAMINO}-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE HEMINAPADISYLATE AS β2 ADRENERGIC RECEPTOR AGONIST

机译:5-(2-{[6-(2,2-二氟-2-苯甲氧基)己基]氨基} -1-羟基乙氧基)-8-羟基喹诺酮-2(1H)-半纤维素甲磺酸酯作为β2肾上腺素能受体激动剂。

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: present invention refers to 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one heminapadisylate of formula (I) wherein n is equal to 2, and to pharmaceutically acceptable solvates thereof. Also, the invention refers to a pharmaceutical composition of the salt of formula (I), to a method of treating the above pathological conditions and to using the salt of formula (I) and to the pharmaceutical composition thereof.;EFFECT: what is prepared is the new salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one effective in treating the pathological pulmonary conditions, particularly asthma or chronic obstructive pulmonary disease.;11 cl, 3 dwg, 6 ex
机译:领域:本发明涉及5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]氨基} -1-羟乙基)-8-羟基喹啉-2(1H) )-式(I)的一半氨基二甲磺酸酯其中n等于2,并且在药学上可接受的溶剂化物。另外,本发明涉及式(I)的盐的药物组合物,治疗上述病理状况的方法以及使用式(I)的盐及其药物组合物。效果:制备了什么是5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]氨基} -1-羟乙基)-8-羟基喹啉-2(1H)的新盐,可有效治疗病理肺部疾病,尤其是哮喘或慢性阻塞性肺疾病。; 11 cl,3 dwg,6 ex

著录项

  • 公开/公告号RU2495029C2

    专利类型

  • 公开/公告日2013-10-10

    原文格式PDF

  • 申请/专利权人 ALMIRAL S.A.;

    申请/专利号RU20090133442

  • 申请日2008-02-08

  • 分类号C07D215/26;A61K31/4704;A61P11;

  • 国家 RU

  • 入库时间 2022-08-21 16:22:50

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