SEQUENCES, ANTIBODIES, METHODS AND NECESSARY FOR DETECTION AND IN VITRO ASSAYING OF PERIOSTIN FOR THE DIAGNOSIS OF MONITORING OR PROGNOSIS OF PATHOLOGIES OR BIOLOGICAL PHENOMENA INVOLVING PERIOSTIN

摘要

Detection sequences of periostin having from 6 to 30 amino acids and which include all or part of peptide sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3, or a homologous peptide sequence. Antibodies suitable for specifically recognizing minimally one of these detection sequences, including an anti-periostin antibody, are disclosed. Periostin detection and dosage processes and kits that use these antibodies are also disclosed. A periostin marker for early diagnosis, tracking and prognosis of pathologies that involve periostin, including benign osteolysis such as inflammatory diseases, including osteoarticular diseases, and malignant osteolysis, such as cancers with bone metastases, is provided.