USE OF AT LEAST ONE BIOMARKER FOR IN VITRO PROGNOSIS OR DIAGNOSIS OF LYMPHOPROLIFERATIVE EPISODES ASSOCIATED WITH EPSTEIN-BARR (EBV) VIRUS

摘要

The present invention relates to a protein complex isolated from its natural environment and comprising the ZEBRA protein of sequence SEQ ID NO: 1, said isolated protein complex having the following properties: it is more stable than the ZEBRA protein, in particular it is more resistant to the action of proteases that the ZEBRA protein, - it is capable of specifically binding the monoclonal antibodies AZ125 and AZ130, - it is soluble in a biological fluid, and in particular a biological fluid selected from the group consisting of blood and serum , and its method of detection and uses of this method for the prognosis or diagnosis of EBV-associated lymphoproliferative episodes.