USE OF INFLUENZA VIRUS AND OIL-IN-WATER EMULSION ADJUVANT FOR INDUCING CD4 T-CELL RESPONSE AND/OR IMPROVED B CELL MEMORY RESPONSE

摘要

PROBLEM TO BE SOLVED: To provide an improved influenza vaccine with improved immunogenicity which is especially needed for an elderly population.SOLUTION: In use of (a) an influenza virus or antigenic preparation thereof, and (b) an oil-in-water emulsion adjuvant in the manufacture of an immunogenic composition for inducing at least one of i) an improved CD4 T-cell immune response, ii) an improved B cell memory response, against the influenza virus or antigenic composition in a human, the oil-in-water emulsion comprises a metabolizable oil, a sterol and an emulsifying agent.