5,6,7-TRIHYDROXYHEPTANOIC ACID AND ANALOGS FOR TREATMENT OF OCULAR DISEASES AND DISEASES ASSOCIATED WITH HYPERPROLIFERATIVE AND ANGIOGENIC RESPONSES

摘要

PROBLEM TO BE SOLVED: To provide 5,6,7-trihydroxyheptanoic acid and analogs.SOLUTION: The present invention is directed to 5,6,7-trihydroxyheptanoic acid and analogs and their methods of use, including ophthalmic compositions. The compounds are particularly useful in treating persons suffering from posterior segment ocular diseases such as diabetic retinopathy and age-related macular degeneration, and disorders characterized by cellular hyperproliferation and angiogenesis, such as chronic rheumatoid arthritis and coronary artery restenosis after balloon angioplasty and cancer.