METHODS OF MODULATING CELLULAR HOMEOSTATIC PATHWAYS AND CELLULAR SURVIVAL

摘要

PROBLEM TO BE SOLVED: To provide methods of modulating cellular homeostatic pathways and cellular survival.SOLUTION: Diabetes is an impaired metabolic response to our body's own insulin so that active muscle cells cannot take up glucose as easily as they should. When diabetes or reduced insulin sensitivity exists, the body attempts to overcome this resistance by secreting more insulin from the pancreas. In that physiologic circumstance, the blood insulin levels are chronically higher, which inhibits fat cells from releasing their energy stores to allow for weight loss. Diabetes is associated with obesity, hypertension, abnormal triglycerides and glucose intolerance. The present invention provides compositions, therapeutic agents, and methods for modulating homeostatic pathways that are useful in treatment and prevention of diabetes, diabetes associated disorders, metabolic disorders, and cancer.