METHODS OF MODULATING CELLULAR HOMEOSTATIC PATHWAYS AND CELLULAR SURVIVAL

摘要

#$%^&*AU2014202832B220160128.pdf#####ABSTRACT The invention provides composition and therapeutic methods for modulating homeostatic pathways that are useful in treatment, and prevention of diabetes, diabetes associated disorders, metabolic disorders and cancer. See Figure 4.WO 2008/137633 PCT/US2008/062345 4/47 Glucose GK G6PO VE-1 PI OG6P Glucose PKA Glucose Metabolism t h* ' Insulin Secretion BH3 Domain BAD Active Multi-Domain BAX/BAK *.e Cytochromec Pro-apoptotics .Re *e* Release ~ID~ ~Mitchz dio.:t BCL-XL Apoptosome Effector MCL-2 Formation Caspases Multi-Domain Anti-apoptotics Fig. 4