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Identification markers for calorie restriction mimetics and caloric restriction
Identification markers for calorie restriction mimetics and caloric restriction
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机译:限制卡路里的模拟物和热量限制的识别标记
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摘要
Markers of caloric restriction (CR) can be identified in a selected tissue by exposing an animal to CR conditions and selecting one or more genes differentially expressed in response to CR conditions in multiple subject groups. A candidate compound can be screened for likely ability to mimic the effects of CR when administered to an animal by comparing the tissue levels of expression products of the genes in animals treated with the candidate compound to those of animals subjected to CR.
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