SPHINGOMYELIN LIPOSOME FOR TREATMENT OF HYPERACTIVE BLADDER DISORDER

摘要

PROBLEM TO BE SOLVED: To provide sphingomyelin liposomes for the treatment of hyperactive bladder disorders.SOLUTION: The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes, preferably containing sphingomyelin or sphingomyelin metabolites, to prevent, manage, ameliorate and/or treat neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis for treating a variety of diseases of animals or humans including inflammation and dysfunction of bladder. A liposome is used as a lipid carrier for the delivery of drugs, e.g. antibiotics, antalgic treatment agents and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body tissue systems. Also, the present invention relates to liposome-based delivery of vanilloid compounds and toxin for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.